What do you think about Springer Nature and its family of nerve growth factor pdf? Tell us in our 10 minute survey. Neurotrophins are critical for the development and maintenance of the peripheral and central nervous system. These highly homologous, homodimeric growth factors control cell survival, differentiation, growth cessation, and apoptosis of sensory neurons.
TrkA and can induce cell death by binding to p75NTR. Recent domain deletion and mutagenesis studies have identified the membrane-proximal domain of the Trks as necessary and sufficient for ligand binding. Crystal structures of this domain of TrkA, TrkB, and TrkC, and an alanine scanning analysis of this domain of TrkA and TrkC have allowed identification of the ligand- binding site. The recent crystal structure of the complex between NGF and the ligand-binding domain of TrkA defines the orientation of NGF in the signaling complex, and eludicates the structural basis for binding and specificity in the family.
Further structural work on NGF-TrkA- p7SNTR complexes will be necessary to address the many remaining questions in this complex signaling system. Department of Protein Engineering, Genentech, Inc. 2017 Springer International Publishing AG. It is perhaps the prototypical growth factor, in that it was one of the first to be described.